Plexine A4 (PLXNA4) (NM 181775) Humaan Recombinant Proteïne

Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity) .[UniProtKB/Swiss-Prot Function]

Purified recombinant protein of Human plexin A4 (PLXNA4), transcript variant 2, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug

FAYV2820; PLEXA4; PLXNA4A; PLXNA4B; PRO34003

91584

Q9HCM2

NM_181775

7q32.3

E. coli

N-GST and C-His

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

Druggable Genome

86 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

PLXNA4

Human

NP_861440

https://www.ncbi.nlm.nih.gov/gene/91584

https://www.uniprot.org/uniprot/Q9HCM2

https://www.ncbi.nlm.nih.gov/nuccore/NM_181775

https://www.ncbi.nlm.nih.gov/nuccore/NP_861440