PLGF-eiwit (mFc-dag)

Placental growth factor (PGF) is also known as vascular endothelial growth factor-related protein, PLGF and PlGF2, is a member of the VEGF (vascular endothelial growth factor) sub-family - a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast. PGF is actived in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. PlGF2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.

D12S1900 Protein; PGFL Protein; PIGF Protein; PLGF Protein; PlGF-2 Protein; SHGC-10760 Protein

NP_002623.2

Human

Human

MFc-Tag

See Datasheet send with the product

< 1.0 EU per μg protein as determined by the LAL method.

> 95 % as determined by SDS-PAGE.

1. Immobilized human PGF-mFc at 10 μg/mL (100 μL/well) can bind human VEGFR1-His. The EC50 of human VEGFR1-His is 0.19-0.43 μg/mL. 2. Labeled biotin to PLGF / PGF Protein, Human, Recombinant (Fc Tag) by a certain molar ratio; Using the Octet RED System, the affinity constant (Kd) of PLGF / PGF Protein, Human, Recombinant (Fc Tag), Biotinylated bound to Conbercept was 4.5 nM.

386

Lyophilized

PBS, pH 7.4

See Datasheet

44 kDa

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

HEK 293 cells