PLOD2 Antilichaam - middengebied HRP (ARP42731 P050-HRP)

Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

LH2, TLH, BRKS2

5352

O00469-2

NP_891988

Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human PLOD2

PLOD2 forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

ITGB1BP2; SUPT5H; CSDE1; SF1; UGP2; TPP2; VASN; RNF123; NUSAP1; SAMHD1; DNPEP; GANAB; SWAP70; XPO7; PACSIN2; FAF1; HSPH1; SEC23A; PRMT3; FARSB; USP15; RANBP3; SET; RPL24; PTPN12; NCL; NARS; JUP; GART; XRCC6; AP2B1; gag-pol; UBL4A; OS9; FBXO6; UBC; VHL; Fa

HRP: Horseradish Peroxidase

Polyclonal Antibody

IHC, WB

Affinity Purified

PLOD2 is strongly supported by BioGPS gene expression data to be expressed in DU145

0.5 mg/ml

Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

84kDa

Ewing, R.M., Mol. Syst. Biol. 3, 89 (2007)

Wet Ice

758

PLOD2

PLOD2

Rabbit

Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

NM_182943

IKGKTLRSEMNERNYFVRDKLDPDMALCRNAREMTLQREKDSPTPETFQM