PLX4720
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Potent and selective inhibitor of B-Raf, V600E mutant, IC50=13 nM (Wild type IC50=160 nM) .1 It induces cell cycle arrest and apoptosis in B-RafV600E-positive cells and suppresses growth of B-RafV600E-positive xenografts.1 It induces tumor regression and reverses cachexia in a mouse model of human thyroid cancer harboring the B-RafV600E mutation.2 Early stage autophagy inhibitors and ER stress inhibition with 4-phenylbutyric acid increases the sensitivity of resistant cells to PLX4720.3 PLX4720 induces cytoprotective autophagy in thyroid cancer cells via AMPK-ULK1 pathway.4
Unconjugated
White solid
-20°C
Beschrijving
PLX4720 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
Recent bekeken producten
CYP707A2 Antibody
GTR17947107
2 mg
SsDNA Assay Kit
12645ES60
100 Tests
Eco Alu MTP (HxD) 6x7=42 plates 35mm, 223x630x135mm
TE15336
1 Piece
Arachis hypogaea Lectin (PNA) - Biotinylated
21510020-1
5mg
Cellubrevin Antibody
MBS9436639-01
0.05 mL
Oxidative Stress Combo Assay Tissue Kit
EA-7008
1 Each
1,4- Dioxane Pure
1041330 500
500 mL
Benzonase ELISA Kit
EG23601S
96 Tests
Recent gezochte producten
Recombinant Deinococcus radiodurans Protein RecA (recA)
MBS1071366-01
0.05 mg (E-Coli)
Recombinant Deinococcus radiodurans Protein ApaG (apaG)
MBS1302345-01
0.05 mg (E-Coli)
Recombinant Deinococcus radiodurans Protein grpE (grpE)
MBS1306645-01
0.05 mg (E-Coli)
Recombinant Deinococcus radiodurans GTPase obg (obg)
MBS1312662-01
0.05 mg (E-Coli)
Recombinant Deinococcus radiodurans GTPase Era (era)
MBS1418228-01
0.05 mg (E-Coli)
Recombinant Deinococcus radiodurans GTPase Der (der)
MBS1445159-01
0.05 mg (E-Coli)
Recombinant Deinococcus radiodurans Enolase (eno)
MBS1455279-01
0.05 mg (E-Coli)
Recombinant Deinococcus radiodurans Protein nrdI (nrdI)
MBS1483359-01
0.05 mg (E-Coli)