PMEPA1 Antilichaam

The prostate transmembrane protein, androgen induced 1 (PMEPA1) protein is a transmembrane protein that contains a Smad interacting motif (SIM) (1,2) . Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins (3) . Overexpression of this gene may play a role in multiple types of cancer (2,4) .

56937

Q969W9

NP_064567

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Signal Transduction

PMEPA1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1203 - A549 Cell Lysate

1 mg/mL

PMEPA1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PMEPA1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

PMEPA1 antibody is human, mouse and rat reactive. At least four isoforms are known to exist; this antibody will detect all of the isoforms.

PMEPA1

Prostate transmembrane protein, androgen induced 1

Homo sapiens

Xu LL, Shanmugam N, Segawa T, et al. A novel androgen-regulated gene, PMEPA1, located on chromosome 20q!3 exhibits high level expression in prostate. Genomics 2000; 66:257-63.

Rae FK, Hooper JD, Nicol DL, et al. Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors. Mol. Carcinog. 2001; 32:44-53.

Watanabe Y, Itoh S, Goto T, et al. TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling. Mol. Cell 2010; 37:123-34.

Vo Nguyen TT, Watanabe Y, Shiba A, et al. TMEPAI/PMEPA1 enhances tumorigenic activities in lung cancer cells. Cancer Sci. 2014; 105:334-41.

Prostate transmembrane protein androgen induced 1, STAG1, TMEPAI

ELISA, WB, IHC-P

21361841

Liquid