PML Antilichaam - N-terminalgebied: FITC (ARP38184_P050-FITC)

Promyelocytic leukemia

MYL, RNF71, PP8675, TRIM19

5371

P29590

NP_150250

Human

The immunogen is a synthetic peptide directed towards the N terminal region of human PML

PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. PML localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL) . Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL) . Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.

RPL11; RPL5; SUMO1; UBC; TP53; SUMO2; SUMO3; MDM2; RNF4; EGFR; NCOA2; SP100; DAXX; MAPK7; HDAC1; ATXN1; ATRX; ASF1A; EHMT2; HIRA; HTT; H3F3A; ATF7IP; PML; JAK1; EIF4E; GLIS2; UBE2I; smt3; HDAC11; HDAC6; LMNA; RNF111; CDK6; CDK2; CDK1; CASP8AP2; RBX1; SH3G

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Human: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

48kDa

Eun, B., (2008) J. Biol. Chem. 283 (9), 5939-5949

Wet Ice

Isoform 1-14 specific

435

PML

PML

Rabbit

Protein PML

NM_033247

PSPSPSPTERAPASEEEFQFLRCQQCQAEAKCPKLLPCLHTLCSGCLEAS