PMS2 Antilichaam - middengebied: Biotine (ARP56117 P050-Biotine)

PMS2 postmeiotic segregation increased 2 (S. cerevisiae)

MLH4, PMSL2, HNPCC4, MMRCS4, PMS2CL

5395

P54278

NP_000526

Human, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast

The immunogen is a synthetic peptide directed towards the middle region of human PMS2

PMS2 is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors.This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.

UBC; MLH1; PCNA; PMS2P1; NSF; MSH2; LMNA; MSH6; SPRTN; BRIP1; FAN1; CLSPN; TOPBP1; PSD2; MMS19; ATAD3A; NSUN2; UBR5; COPG2; PSD3; COPG1; RUVBL2; EXO1; AIFM1; RUVBL1; XPO1; SMARCA4; RFC2; PSMD5; PSMC6; PSMC3; PSMC2; PSMC1; PRKDC; PPP2CA; PIK3C2A; MSH3; MCM

Biotin

Polyclonal Antibody

WB

Affinity Purified

PMS2 is supported by BioGPS gene expression data to be expressed in HepG2

0.5 mg/ml

Cow: 85%; Dog: 92%; Guinea Pig: 100%; Horse: 92%; Human: 100%; Rabbit: 92%; Rat: 92%; Yeast: 91%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

96kDa

Jackson, C.C., (2008) Pediatr Blood Cancer 50 (6), 1268-1270

Wet Ice

862

PMS2

PMS2

Rabbit

Mismatch repair endonuclease PMS2

NM_000535

INKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAA