Pochonin D

Pochonin D ((+) -Pochonin D) is an inhibitor of heat shock protein 90 (Hsp90) with antiviral and anti-inflammatory activities. Pochonin D inhibits Hsp90, affecting the homeostasis, folding, and assembly processes of viral proteins, reducing the replication ability of the virus. Pochonin D reduces the infiltration of inflammatory cells and the secretion of inflammatory cytokines such as TNF-α and IL-1β, alleviating the inflammatory response. Pochonin D is promising for research of Human rhinoviruses (HRV) infections and cancers[1].

544712-82-5

(+) -Pochonin D

12352101

Enterovirus; HSP; Interleukin Related

Anti-infection; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease

COVID-19-anti-virus

Cancer; Infection; Inflammation/Immunology

ClC1=C2C(C(O[C@@H](C/C=C/CC/C=C/C(C2)=O)C)=O)=C(C=C1O)O

C18H19ClO5

350.79

[1]Song JH, et al. Antiviral and Anti-Inflammatory Activities of Pochonin D, a Heat Shock Protein 90 Inhibitor, against Rhinovirus Infection. Biomol Ther (Seoul) . 2018 Nov 1;26 (6) :576-583.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N14780/

Natural Products

No Development Reported