POFUT1 Antilichaam

POFUT1 Antibody: POFUT1, an endoplasmic reticulum-residing member of the glycosyltransferase O-Fuc family, adds O-fucose through an O-glycosidic linkage to conserved serine or threonines in epidermal growth factor-like repeats of several cell surface and secreted proteins. Unlike its homolog POFUT2, POFUT1 can also catalyze the transfer of fucose to thrombospondin type 1 repeats. Many of the substrates of POFUT1 are involved in ligand-induced receptor signaling. One such protein is Notch; mouse ES cells lacking POFUT have normal levels of Notch receptors at the cell surface, but these receptors do not bind Notch ligands or exhibit Notch signaling.

23509

Q9H488

NP_056167

Human, Mouse

Unconjugated

Primary Antibodies

Signal Transduction

POFUT1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1301 - Human Heart Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (94%)

POFUT1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

POFUT1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least two isoforms of POFUT1 are known to exist. This antibody is predicted to not cross-react with POFUT2.

POFUT1

Cat. No. 10-501 - Human Heart Tissue Slide

Protein O-fucosyltransferase 1

Homo sapiens

Wang Y, Shao L, Shi S, et al. Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase. J. Biol. Chem.2001; 276:40338-45.

Loriol C, Dupuy F, Rampal R, et al. Molecular evolution of protein O-fucosyltransferase genes and splice variants. Glycobiology2006; 16:736-47.

Stahl M, Uemura K, Ge C, et al. Roles of POFUT1 and O-fucose in mammalian Notch signaling. J. Biol. Chem.2008; 283:13638-51.

POFUT1 Antibody: DDD2, FUT12, O-FUT, OFUCT1, O-Fuc-T, O-FucT-1, KIAA0180, GDP-fucose protein O-fucosyltransferase 1, Peptide-O-fucosyltransferase 1

ELISA, WB, IHC-P

27436889

Liquid