POLRMT (CT) Antilichaam

POLRMT Antibody: This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication. POLRMT mutations impair mitochondrial transcription causing neurological disease. Knock-down of MRPL12 by RNA interference results in instability of POLRMT.

5442

O0411

O0411.2

Human, Mouse, Rat

9561

Unconjugated

Primary Antibodies

Signal Transduction

POLRMT Antibody is affinity chromatography purified via peptide column.

Cat. No. 1203 - A549 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Cow (82%) ; Chimpanzee (100%) ; monkey (82%) ; Cat (90%)

POLRMT Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

POLRMT antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human POLRMT has 1 isoform (1230aa, 138.6kD) . Mouse POLRMT has one isoform (1207aa, 136.7kD) . Rat POLRMT has one isoform (1203aa, 135.8kD) . 9561 can detect POLRMT in human, mouse and rat.

POLRMT

Cat. No. 1224 - Daudi Cell Lysate

RNA polymerase mitochondrial

Homo sapiens

Inatomi et al. Biochim Biophys Acta Mol Cell Res. 2022; 1869 (1) ; 119167

Olahova et al. Nat Commun. 2021; 12 (1) :1135

Nouws et al. J Biol Chem 2016; 291 (2) :989-997

DNA-directed RNA polymerase, mitochondrial, MtRPOL, POLRMT Isoforms

ELISA, WB, IF

50403691

Liquid