POLRMT (CT) Peptide

POLRMT Antibody: This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication. POLRMT mutations impair mitochondrial transcription causing neurological disease. Knock-down of MRPL12 by RNA interference results in instability of POLRMT.

5442

O0411

O0411.2

Peptides

200 ug/mL

PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide

Blue Ice

Store ULBP1 peptide at -20˚ C, stable for one year.

POLRMT (CT) Peptide is used for blocking the activity of POLRMT (CT) Antibody.

RNA polymerase mitochondrial

Homo sapiens

Inatomi et al. Biochim Biophys Acta Mol Cell Res. 2022; 1869 (1) ; 119167

Olahova et al. Nat Commun. 2021; 12 (1) :1135

Nouws et al. J Biol Chem 2016; 291 (2) :989-997

DNA-directed RNA polymerase, mitochondrial, MtRPOL, POLRMT Isoforms

Blocking

Human

50403691

Liquid