Polyporeenzuur C (standaard)

Polyporenic acid C (Standard) is an analytical standard of Polyporenic acid C. This product is intended for research and analytical applications. Polyporenic acid C is a lanostane-type triterpenoid. Polyporenic acid C can be isolated from Poria cocos. Polyporenic acid C causes the cleavage of caspase-8 and caspase-3, as well as the cleavage of PARP. Polyporenic acid C reduces the phosphorylation level of Akt (Ser473), increases the phosphorylation of PTEN and p53 (Ser15), and activates JNK. Polyporenic acid C induces Apoptosis. Polyporenic acid C shows anticancer activity against non-small cell lung cancer[1].

465-18-9

12352211

Akt; Apoptosis; Caspase; JNK; MDM-2/p53; PARP; PTEN

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; MAPK/ERK Pathway; PI3K/Akt/mTOR

Cancer

C[C@]12[C@@]([C@]([C@H](C(O)=O)CCC(C(C)C)=C)([H])[C@H](O)C1)(CC=C3C2=CC[C@](C4(C)C)([H])[C@@]3(CCC4=O)C)C

C31H46O4

482.69

[1]Ling H, et al. Polyporenic acid C induces caspase-8-mediated apoptosis in human lung cancer A549 cells.Mol Carcinog. 2009 Jun;48 (6) :498-507.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N2993R/

Reference Standards

Caspase 3; Caspase 8