Poneratoxine (acetaat)

Poneratoxin acetate is the acetate salt form of Poneratoxin. Poneratoxin acetate is the modulator for voltage-gated sodium channel (NaV, EC50 for NaV1.6 and NaV1.7 is 97 nM and 2.3 µM), that lowers the voltage threshold for activation and inhibits the inactivation of channels, enhances the excitability of neurons, and leads to the transmission of pain signals[1].

12352209

Sodium Channel

Membrane Transporter/Ion Channel

Neuroscience-Neuromodulation

Neurological Disease

98.77

DMSO : 125 mg/mL (ultrasonic)

O=C(N[C@@H](CC(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N[C@@H]([C@H](O)C)C(N2[C@@H](CCC2)C(N3[C@@H](CCC3)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC5=CC=CC=C5)N.CC(O)=O.[x]

C129H215N33O31S.xC2H4O2

2756.35 (free base)

[1]Robinson SD, et al., Ant venoms contain vertebrate-selective pain-causing sodium channel toxins. Nat Commun. 2023 May 23;14 (1) :2977.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P10234A/Poneratoxin-acetate-SDS-MedChemExpress.pdf

Peptides

No Development Reported

PLoS Biol. 2025 Nov 24;23 (11) :e3003513.|Bioorg Med Chem. 2025 Oct 9:132:118436.|Sci Rep. 2025 Jul 16;15 (1) :25854.