POU2F3 Antilichaam

POU2F3, also known as Epoc-1, is a member of a family of POU domain family of transcription factors (1) . POU2F3 is expressed primarily in the epidermis and plays a critical role in keratinocyte proliferation and differentiation (1,2) . It is a crucial transcription factor that is required for the development of sweet, umami, and bitter, but not sour taste receptor cells (3) . POU2F3 is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer (4) .

25833

Q9UKI9

NP_001231611

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

POU2F3 antibody is affinity chromatography purified via peptide column.

Cat. No. 1220 - SK-N-SH Cell Lysate

1 mg/mL

POU2F3 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

POU2F3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

POU2F3 antibody is human, mouse and rat reactive. At least two isoforms are known to exist. This antibody will recognize both isoforms. POU2F3 antibody is predicted to not cross-react with other members of the POU domain class 2 family.

POU2F3

POU class 2 homeobox 3

Homo sapiens

Yukawa K, Yasui T, Yamamoto A, et al. Epoc-1: a POU-domain gene expressed in murine epidermal basal cells and thymic stromal cells. Gene 1993; 133:163-9.

Cabral A, Fischer DF, Vermeij WP, et al. Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation. J. Biol. Chem. 2003; 278:17792-9.

Matsumoto I, Ohmoto M, Narukawa M, et al. Skn-1a/Pou2f3 specifies taste receptor cell lineage. Nat. Neurosci. 2011; 14:685-7.

Zhang Z, Huettner PC, Nguyen L, et al. Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer. Oncogene 2006; 25:5436-45.

POU2F3 Antibody: PLA1, OCT11, PLA-1, Epoc-1, OCT-11, OTF-11, Skn-1a, OTF11, PLA1, POU domain, class 2, transcription factor 3, Octamer-binding protein 11, 41923

ELISA, WB, IHC-P, IF

347658964

Liquid