PPARA Antilichaam - N-terminalgebied: Biotine (ARP33066_P050-Biotine)

Peroxisome proliferator-activated receptor alpha

PPAR, NR1C1, hPPAR, PPARalpha, PPAR-alpha

5465

Q07869

NP_005027

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the n terminal region of human PPARA

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. PPARA is the subtype PPAR-alpha, which is a nuclear transcription factor.Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.

SIRT1; PRMT1; PRMT8; RXRA; CHD9; NCOA1; FOXA3; CDK3; TNP1; HSP90AA1; NCOR2; NCOR1; SUMO1; UBE2I; LPIN1; SRC; TRA; MECR; STAC3; HELZ2; NRBF2; AIP; NR1H3; MED24; GADD45G; GADD45B; AKAP13; PPARGC1A; MED1; EP300; NRIP1; DAP3; MAPK3; DUT; RXRG; PRKCD; PRKCA; M

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 93%; Dog: 93%; Goat: 93%; Guinea Pig: 92%; Horse: 86%; Human: 100%; Mouse: 79%; Rabbit: 86%; Rat: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

52kDa

Kourimate, S., (2008) J. Biol. Chem. 283 (15), 9666-9673

Wet Ice

468

PPARA

PPARA

Rabbit

Peroxisome proliferator-activated receptor alpha

NM_005036

EISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPV