PPARD Antilichaam - middengebied: Biotine (ARP32878 T100-Biotine)

Peroxisome proliferator-activated receptor delta

FAAR, NUC1, NUCI, NR1C2, NUCII, PPARB

5467

Q03181

NP_006229

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human PPARD

PPARD is a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR delta and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.

KRTAP10-3; KRTAP10-7; PLA2G4A; CTNNB1; KDM1A; PRMT3; SMAD9; HSP90AA1; TNP1; PSMG1; Nedd4; RANBP9; PRDX6; EIF3I; NCOA1; NR0B2; SHMT2; RXRG; RXRB; RXRA; PROX1; ITGB5; GLUL; RELA; HDAC1; EP300; NCOA2; SRC; SPEN; HDAC7; HDAC3; PEBP1; HDAC2; GADD45G; GADD45B

Biotin

Polyclonal Antibody

WB

0.5 mg/ml

Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 92%; Human: 100%; Mouse: 92%; Rabbit: 93%; Rat: 100%; Zebrafish: 92%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

49kDa

Barish, G.D., et al., (2006) J. Clin. Invest. 116 (3), 590-597

Wet Ice

441

PPARD

PPARD

Rabbit

Peroxisome proliferator-activated receptor delta

NM_006238

NPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIET