PPARGC1A Antilichaam

The peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A), also known as LEM-6, is a transcriptional coactivator that regulates the genes involved in energy metabolism (1) . PPARGC1A interacts with PPARgamma, which permits the interaction of PPARGC1A with multiple transcription factors. PPARGC1A can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs) . It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination (2) . PPARGC1A may be also involved in the development of obesity (3) .

10891

Q9UBK2

NP_037393

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Obesity

PPARGC1A antibody is affinity chromatography purified via peptide column.

Cat. No. 1404 - Mouse Liver Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Pig: (100%), Bovine: (100%)

PPARGC1A antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PPARGC1A antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

PPARGC1A antibody is human, mouse and rat reactive. At least three isoforms of PPARGC1A are known to exist; this antibody only detects the longest isoform.

PPARGC1A

Cat. No. 10-201 - Human Liver Tissue Slide

Cat. No. 1304 – Human Liver Tissue Lysate

Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

Homo sapiens

Tsuemi T and La Spada AR. PGC-1a at the intersection of bioenergetics regulation and neuron function: from Huntington's disease to Parkinson's disease and beyond. Prog. Neurobiol. 2012; 97:142-51.

Kang C and Li Ji L. Role of PGC-1a signaling in skeletal muscle health and disease. Ann. NY Acad. Sci. 2012; 1271:110-7.

Liu C and Lin JD. PGC-1 coactivators in the control of energy metabolism. Acta Biochim. Biophys. Sin. 2011; 43:248-57.

PPARGC1A Antibody: LEM6, PGC1, PGC1A, PGC-1v, PPARGC1, PGC-1 (alpha), LEM6, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, Ligand effect modulator 6, PGC-1-alpha

ELISA, WB, IHC-P, IF

7019499

Liquid