PPIA Antilichaam - middengebied: FITC (ARP51352 T100-FITC)

Peptidylprolyl isomerase A (cyclophilin A)

CYPA, CYPH, HEL-S-69p

5478

P62937

NP_066953

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Sheep

The immunogen is a synthetic peptide directed towards the middle region of human PPIA

PPIA is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. PPIA is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions.The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a cyclosporin binding-protein. It may play a role in cyclosporin A-mediated immunosuppression. This protein can interact with several HIV proteins including p55 gag, Vpr, and capsid protein. It has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. Three alternatively spliced transcript variants encoding two distinct isoforms have been observed.

LNX1; HUWE1; UBC; TCF4; FUS; gag; MDM2; RPL23A; SRPK2; SRPK1; ESR1; UBD; TERT; RAD52; VCAM1; ITGA4; FN1; HCVgp1; LIG4; PAXIP1; RB1; APP; CPLX1; SNX3; TAGLN2; SOD1; RPA2; RAD23B; PTMA; IGBP1; ENO1; AKT1; USP4; CDK2; COPS5; CUL1; CUL3; CUL4B; NEDD8; CD99; C

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

IHC, WB

PPIA is strongly supported by BioGPS gene expression data to be expressed in HepG2

0.5 mg/ml

Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%; Sheep: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

18kDa

Sokolskaja, E., (2006) J. Virol. 80 (6), 2855-2862

Wet Ice

165

PPIA

PPIA

Rabbit

Peptidyl-prolyl cis-trans isomerase A

NM_021130

TAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE