PPL Antilichaam - middelste regio : HRP (ARP42061 P050-HRP)

Periplakin

KIAA0568, MGC134872

5493

O60437

NP_002696

Human, Pig

The immunogen is a synthetic peptide directed towards the middle region of human PPL

PPL is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

CEP57L1; ZSCAN1; RAB3IP; TSC22D4; RALBP1; AHCYL1; VIM; TRAF2; TRIM27; ALAS1; AKT1; SKIL; UBC; USP7; CUL1; ITSN1; Cdk1; KAZN; PPHLN1; EVPL; CASP6; OPRM1; COL17A1; KRT8; EZR

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

PPL is supported by BioGPS gene expression data to be expressed in MCF7

0.5 mg/ml

Human: 100%; Pig: 82%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

205kDa

Boczonadi, V., (2007) Exp. Cell Res. 313 (16), 3579-3591

Wet Ice

1756

PPL

PPL

Rabbit

Periplakin

NM_002705

EKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSF