PPP1CA Antibody - N-terminal regio : HRP (ARP58652_P050-HRP)

Protein phosphatase 1, catalytic subunit, alpha isozyme

PP1A, PP-1A, PPP1A, PP1alpha

5499

Q07161

NP_001008709

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human PPP1CA

PPP1CA is one of the three catalytic subunits of protein phosphatase 1 (PP1) . PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory.The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1) . PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.

HUWE1; PPP1R2P3; CSRNP2; CSRNP1; UBC; SUMO2; SUMO3; BRCA1; Kctd20; WWOX; PKM; SCPEP1; TMOD3; MAT2B; STK24; YWHAH; XPO1; TBCB; CAPNS1; ALDH7A1; ASNS; YAP1; LMTK2; RB1; POLR2A; GSK3B; MST1R; IKBKB; CHUK; CTDP1; TNFRSF1A; tat; PPP1R15A; PPP1R13B; PLCL2; CD2B

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

PPP1CA is supported by BioGPS gene expression data to be expressed in Jurkat

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

38kDa

Lesage, B., (2007) Biochemistry 46 (31), 8909-8919

Wet Ice

341

PPP1CA

PPP1CA

Rabbit

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

NM_001008709

MSDSEKLNLDSIIGRLLEGSRVLTPHCAPVQGSRPGKNVQLTENEIRGLC