PPP4C Antilichaam - middengebied: HRP (ARP58516_P050-HRP)

Protein phosphatase 4, catalytic subunit

PP4, PPX, PP-X, PP4C, PPH3, PPP4

5531

P60510

NP_002711

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human PPP4C

PPP4C is a protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF) -alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDC2/Cdk1 phosphorylation sites and negatively regulates CDC2/Cdk1 activity in interphase.

SUMO2; IKBKG; MAP4K1; BAG6; TCP1; UBC; CAND1; CUL3; Igbp1; TRIM28; ELAVL1; TK1; PPP2R5D; PPP2R4; PPP2R2B; PPP2R1A; EEF1A1; CCT6A; SMEK2; PPP2R2D; SMEK1; ATAD3A; PPME1; CCT5; CCT8; CCT2; CCT4; CCT7; PPP4R1; PLOD3; CCDC6; TUBA3C; CCT3; CCT6P1; GLYATL3; PPP4

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 79%; Zebrafish: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

34kDa

Humphray, S.J., (2008) J. Cell Biol. 180 (6), 1133-1147

Wet Ice

307

PPP4C

PPP4C

Rabbit

Serine/threonine-protein phosphatase 4 catalytic subunit

NM_002720

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