PRAME Antilichaam - N-terminaal gebied: Biotine (ARP55982 P050-Biotine)

Preferentially expressed antigen in melanoma

MAPE, OIP4, CT130, OIP-4

23532

P78395

NP_006106

Human, Mouse, Rat, Cow, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human PRAME

PRAME functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. PRAME prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.

PRAME; RBX1; CUL2; TCEB2; TCEB1; ZNF408; FBXL12; XRN2; HIST4H4; HIST2H2BE; HIST2H2AC; HIST3H3; UBC; RARA; TP53RK; OSGEP; TPRKB; KDM1A; BAG2; LAGE3; UBL4A; SNRPB; RPS13; RPL22; RPL10; RFC4; PSMC4; HNRNPM; HNRNPH1; HNRNPF; HNRNPC; NEDD8; STK19

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 92%; Horse: 79%; Human: 100%; Mouse: 92%; Rabbit: 79%; Rat: 92%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

56kDa

Ikeda, H., (2007) Leuk. Res. 31 (11), 1521-1528

Wet Ice

509

PRAME

PRAME

Rabbit

Melanoma antigen preferentially expressed in tumors

NM_006115

AMVQAWPFTCLPLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQ