Prexasertib-d4
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Prexasertib-d4 (LY2606368-d4) is the deuterium labeled Prexasertib. Prexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of 50=8 nM) and RSK1 (IC50=9 nM). Prexasertib causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib shows potent anti-tumor activity[1][2].
LY2606368-d4
12352005
Apoptosis; Checkpoint Kinase (Chk) ; Isotope-Labeled Compounds
Apoptosis; Cell Cycle/DNA Damage; Others
Cancer
NC([2H])([2H])CC([2H])([2H])OC(C=CC=C1OC)=C1C2=CC(NC3=NC=C(C#N)N=C3)=NN2
C18H15D4N7O2
369.41
[1]King C, et al. LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms. Mol Cancer Ther. 2015 Sep;14 (9) :2004-1|[2]Yin Y, et al. Chk1 inhibition potentiates the therapeutic efficacy of PARP inhibitor BMN673 in gastric cancer. Am J Cancer Res. 2017 Mar 1;7 (3) :473-483.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-18174S/
Isotope-Labeled Compounds
No Development Reported
Beschrijving
Prexasertib-d4 (LY2606368-d4) is the deuterium labeled Prexasertib. Prexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase
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