PRICKLE1 Antilichaam

PRICKLE1 Antibody: PRICKLE1, also known as RILP or EPM1B, is a Disheveled-associated protein that serves as a nuclear translocation receptor for REST/NRSF and REST4 (1, 2) . It contains three N-terminal LIM domains and three C-terminal nuclear localization signals. It localizes to the cytoplasm, as well as to the nuclear membrane and expressed at higher levels in placenta. PRICKLE1 is a negative regulator of the Wnt / beta-catenin signaling pathway and is a putative tumor suppressor in human HCCs. Defects in the gene encoding PRICKLE1 are associated with autosomal recessive progressive myoclonic epilepsy.

144165

Q96MT3

NP_694571

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

PRICKLE1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1310 - Human Bladder Tissue Lysate

1 mg/mL

PRICKLE1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PRICKLE1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Multiple isoforms of PRICKLE1 are known to exist. PRICKLE1 antibody is predicted to not cross-react with other PRICKLE protein family members.

PRICKLE1

Prickle homolog 1

Homo sapiens

Katoh M and Katoh M. Identification and characterization of human PRICKLE1 and PRICKLE2 genes as well as mouse Prickle1 and Prickle2 genes homologous to Drosophila tissue polarity gene prickle. Int. J. Mol. Med. 2003; 11:249-56

Shimojo M and Hersh LB. REST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor. Mol. Cell. Biol. 2003; 23:9025-31

Chan DW, Chan CY, Yam JW, et al. Prickle1 negatively regulates Wnt/β -catenin pathway by promoting Disheveled ubiquitination/degradation in liver cancer. Gastroenterology 2006; 131:1218-27.

Tao H, Manak JR, Sowers L, et al. Mutations in prickle orthologs cause seizures in flies, mice, and humans. Am. J. Hum. Genet. 2011; 88:138-49.

PRICKLE1 Antibody: RILP, EPM1B, RILP, Prickle-like protein 1

ELISA, WB, IF

222136684

Liquid