PRIMA-1MET
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
PRIMA-1MET reactivates mutant p53, an important tumor suppressor gene, in cancer cells.1 It induces p53-dependent mitochondrial apoptosis via activation of caspase-2.2 PRIMA-1MET showed significant antitumor activity in multiple myeloma via activation of p733 and had previously been shown to target p53 family members p63 and p734. Tumor cell death by PRIMA-1MET has been also shown to be caused by glutathione depletion and induced ROS production in a p53 independent manner.5-7 PRIMA-1MET probably induces tumor cell death by both reactivating mutant p53 and inhibiting cellular thiol-dependent redox systems.8
Unconjugated
White solid
-20°C
Beschrijving
PRIMA-1MET Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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