PRKAR1A Antilichaam - C-terminaal gebied: Biotine (ARP57832 P050-Biotine)

Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)

CAR, CNC, CNC1, PKR1, TSE1, ADOHR, PPNAD1, PRKAR1, ACRDYS1

5573

P10644

NP_997636

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish

The immunogen is a synthetic peptide directed towards the C terminal region of human PRKAR1A

CAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC) . This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40) . Three alternatively spliced transcript variants encoding the same protein have been observed.

UBC; RAF1; MAPT; CEP250; GSK3B; AGO3; AGO2; ARPC3; PFDN5; DYRK1B; SET; DYRK1A; PLEKHF2; AKAP10; SOX2; PRKACB; PRKACA; NPM1; CAPN11; RFC2; PPP1CA; SMAD2; HIVEP1; SETD7; PRPF40A; CDK2; CCNE1; SMURF1; Akap7; MEN1; HSP90AA4P; SLC38A5; PRPF31; SAFB; UBD; PATZ1

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

43kDa

Wet Ice

381

PRKAR1A

PRKAR1A

Rabbit

CAMP-dependent protein kinase type I-alpha regulatory subunit

NM_212471

MNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLS