PRKCDBP Antilichaam

PRKCDBP Antibody: The protein kinase C delta (PKC-δ ) binding protein (PRKCDBP), also known as cavin-3, is a member of the cavin family of proteins that are involved in caveolin formation and regulation. PRKCDBP was initially identified in a screen of cultured cell lines for proteins that were strongly induced by serum starvation. Studies indicate that PRKCDBP binds not only to PKC-δ but also to caveolin-1 and helps regulate caveolin traffic and function. Similar to other members of the cavin family, the expression of PRKCDBP was found to be down-regulated in various cancer cell lines, suggesting a possible tumor suppressor function of PRKCDBP.

112464

Q969G5

NP_659477

Human, Mouse

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

PRKCDBP Antibody is affinity chromatography purified via peptide column.

Cat. No. 1288 - A20 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (100%)

PRKCDBP Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PRKCDBP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

29 kDa

IgG

It is predicted to not cross-react with other members of the cavin family.

PRKCDBP

Cat. No. 10-901 - Human Spleen Tissue Slide

Protein kinase C, delta binding protei

Homo sapiens

Briand N, Dugail I, and Le Lay S. Cavin proteins: New players in the caveolae field. Biochimie 2011; 93:71-7.

Izumi Y, Hirai S, Tamai Y, et al. A protein kinase Cdelta-binding protein SRBC whose expression is induced by serum starvation. J. Biol. Chem. 1997; 272:7381-9.

McMahon K, Zajicek H, Li W, et al. SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function. EMBO J. 2009; 28:1001-15.

Bai L, Deng X, Li Q, et al. Down-regulation of the cavin family proteins in breast cancer. J. Cell Biochem. 2012; 113:322-8.

PRKCDBP Antibody: SRBC, HSRBC, CAVIN3, cavin-3, SRBC, Protein kinase C delta-binding protein, Cavin-3, hSRBC

ELISA, WB, IHC-P, IF

47132587

Liquid