PRKCI Antibody - middle area : HRP (ARP56427 P050-HRP)

Protein kinase C, iota

PKCI, DXS1179E, nPKC-iota

5584

P41743

NP_002731

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human PRKCI

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.

PARD6B; PARD6A; UBC; AMOT; SQSTM1; CRX; NPM1; IKBKG; YWHAE; IL1RAP; HSP90AA1; GAB1; CASP8; PARD3; APP; UBD; MAP2K5; MARK2; ARHGAP17; TJP1; ELAVL1; CDK7; MBP; TSC22D1; TTR; FABP4; PARD6G; MARK4; CDC37; RAPGEF2; PNMA1; NIPSNAP1; YWHAZ; YWHAH; MYO10; LLGL1

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

68kDa

Wet Ice

596

PRKCI

PRKCI

Rabbit

Protein kinase C iota type

NM_002740

TVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGS