PRMT2 Antilichaam - N-terminaal gebied: Biotine (ARP40195 P050-Biotine)

Protein arginine methyltransferase 2

HRMT1L1

3275

P55345

NP_001526

Human, Rat

The immunogen is a synthetic peptide directed towards the N terminal region of human PRMT2

The protein arginine methyltransferases (PRMTs) include a family of proteins with related putative methyltransferase domains that modify chromatin and regulate cellular transcription. PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis and it exerts this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, increasing nuclear IkappaB-alpha and decreasing NF-kappaB DNA binding. PRMT2 also rendered cells susceptible to apoptosis by cytokines or cytotoxic drugs, likely due to its effects on NF-kappaB.

FIP1L1; SPAG8; RIPK2; BAG6; RB1; HNRNPA1; E2F1; UBC; PSMB3; HHV8GK18_gp81; CPSF7; DMRTB1; HNRNPUL1; PRMT2; THRB; PGR; NCOA6; NCOA1; ESR2; RXRA; PRRC2A; ESR1; PPARG; RARA

Biotin

Polyclonal Antibody

WB, CHIP

Affinity Purified

PRMT2 is strongly supported by BioGPS gene expression data to be expressed in HEK293T

0.5 mg/ml

Human: 100%; Rat: 79%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

49kDa

Meyer, R., J. Steroid Biochem. Mol. Biol. 107 (1-2), 1-14 (2007)

Wet Ice

433

PRMT2

PRMT2

Rabbit

Protein arginine N-methyltransferase 2

NM_001535

ERAGCCGYIPANHVGKHVDEYDPEDTWQDEEYFGSYGTLKLHLEMLADQP