PRMT5 Antilichaam

Arginine methylation is an irreversible post translational modification which has only recently been linked to protein activity. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These protein include nuclear proteins, IL enhancer binding factor, nuclear factors, cell cycle proteins, signal transduction proteins, apoptosis proteins, and viral proteins. The mammalian PRMT family currently consists of 7 members that share two large domains of homology. Outside of these domains, epitopes were identified and antibodies against all 7 PRMT members have been developed.

10419

O14744

O14744

Human

This PRMT5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 591-621 amino acids from the C-terminal region of human PRMT5.

Unconjugated

Primary Antibodies

Other

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Batch dependent

Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Mouse

Supplied in PBS with 0.09% (W/V) sodium azide.

None

Blue Ice

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

73 kDa

Rabbit Ig

PRMT5

Protein arginine N-methyltransferase 5

Homo sapiens

Pal, S., et al., Mol. Cell. Biol. 23 (21) :7475-7487 (2003) .

Rho, J., et al., J. Biol. Chem. 276 (14) :11393-11401 (2001) .

Pollack, B.P., et al., J. Biol. Chem. 274 (44) :31531-31542 (1999) .

Gilbreth, M., et al., Proc. Natl. Acad. Sci. U.S.A. 95 (25) :14781-14786 (1998) .

Protein arginine N-methyltransferase 5, 211-, 72 kDa ICln-binding protein, Histone-arginine N-methyltransferase PRMT5, Jak-binding protein 1, Shk1 kinase-binding protein 1 homolog, SKB1 homolog, SKB1Hs, Protein arginine N-methyltransferase 5, N-terminally processed, PRMT5, HRMT1L5, IBP72, JBP1, SKB1

WB, IHC-P

Liquid