Probenecide (natrium)

Probenecid sodium is the sodium salt of Probenecid. Probenecid is an effective selective transient receptor potential vanilloid 2 (TRPV2) agonist. Probenecid also inhibits the pannexin 1 channel[1][2][3][4].

23795-03-1

12352005

H302, H315, H319, H335

Bacterial; HIV; TRP Channel

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

COVID-19-anti-virus

Infection

10mM

99.37

DMSO : ≥ 100 mg/mL

O=C(C1=CC=C(S(=O)(N(CCC)CCC)=O)C=C1)O[Na]

C13H18NNaO4S

307.34

H302, H315, H319, H335

[1]Koch SE, et al. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. J Mol Cell Cardiol. 2012 Jul;53 (1) :134-44.|[2]Bakos E, et al. Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57 (4) :760-8.|[3]Greene TA, et al. Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. PLoS One. 2011;6 (5) :e20123.|[4]Silverman W, et al. Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol. 2008 Sep;295 (3) :C761-7.

Room Temperature

4°C (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-W404916/Probenecid-sodium-SDS-MedChemExpress.pdf

Reference compound1

Phase 4

TRPV2