Procyanidine B2-3'-O-gallate

Procyanidin B2-3'-O-gallate is a mono-gallate ester that can be isolated from grape seed extract. Procyanidin B2-3'-O-gallate has anti-cancer efficacy and reduces the viability of prostate carcinoma LNCaP cells. Furthermore, Procyanidin B2-3'-O-gallate induces apoptosis, and causes caspases-9 and -3 and PARP cleavage, and down-regulates Bcl-2, Bcl-Xl and androgen receptor levels[1].

109280-47-9

12352005

Androgen Receptor; Apoptosis; Bcl-2 Family; Caspase; PARP

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Vitamin D Related/Nuclear Receptor

Cancer

O=C(C1=CC(O)=C(O)C(O)=C1)O[C@H]2[C@H](OC3=CC(O)=CC(O)=C3[C@@H]2C4=C(C=C(C(C5)=C4O[C@@H]([C@@H]5O)C(C=C6)=CC(O)=C6O)O)O)C(C=C7)=CC(O)=C7O

C37H30O16

730.62

[1]Chou SC, et al. Influence of gallate esterification on the activity of procyanidin B2 in androgen-dependent human prostate carcinoma LNCaP cells. Pharm Res. 2010 Apr;27 (4) :619-27.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N16483/

Natural Products

No Development Reported

Bcl-2; Bcl-xL; Caspase 3; Caspase 9; PARP