Progesteronreceptor (fosfo Ser190) Antilichaam

Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid, glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by progesterone receptors is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-κ B, AP-1 or STAT. Progesterone receptors are found in the female reproductive tract, mammary glands, brain and pituitary gland and receptor expression is induced by estrogen. Well established functions of progesterone receptors include ovulation, implantation, mammary gland development and maintenance of pregnancy. In addition, progesterone, signaling through the progesterone receptor, increases the ventilatory response of the respiratory centers to carbon dioxide and decreases arterial and alveolar PCO2 in the luteal phase of the menstrual cycle and during pregnancy. The human gene encoding the progesterone receptor has been localized to 11q22.

5241

P06401

NP_000917.3

Human

Progesterone Receptor (Phospho-Ser190) antibody was raised against a peptide sequence around phosphorylation site of serine 190 (G-L-S (p) -P-A) derived from Human Progesterone Receptor.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

99 kDa

This antibody detects endogenous level of Progesterone Receptor only when phosphorylated at serine 190.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

PGR

Progesterone receptor

Homo sapiens

Narayanan R, et al. (2005) Mol Cell Biol; 25 (8) : 2885-98. Knotts TA, et al. (2001) J Biol Chem; 276 (11) : 8475-83. Clemm DL, et al. (2000) Mol Endocrinol; 14 (1) : 52-65. Zhang Y, et al. (1997) Mol Endocrinol; 11 (6) : 823-32

PR, NR3C3, IL10R, PGR, PRGR

WB, IHC, IF

110611914

Liquid