Prolactine, antagonist (1-9) G129R

Prolactin, also known as mammotrophin, luterotropic hormone, and lutetropin, is a neuroendocrine hormone secreted by the pituitary gland. Its primary function is to promote and maintain lactation during pregnancy and suckling. In addition, Prolactin plays an immune-regulatory role by stimulating the activities of ornithine decarboxylase and protein kinase C, which are important for the proliferation, differentiation, and function of lymphocytes. Recombinant human prolactin antagonist del 1-9 G129R mutant has a molecular weight of approx. 22 kDa and contains 190 amino acid residues with an additional N-terminal Alanin.

Mammotropin, Luterotropic hormone, Lutetropin, PRL

5617

P01236

NP_000939.1

NM_000948

6p22.2-p21.3

Human

Human

It is recommended to reconstitute the lyophilized hPRL in sterile water or 0.4% NaHCO3 adjusted tp pH 8-9, not less than 100µg/ml, which can then be further diluted to other aqueous solutions, preferably in presence of carrier protein.

< 0.1 ng/µg of protein (< 1EU/µg)

> 97% by SDS-PAGE & Gel Filtration

Determined by its ability to inhibit hPRL-induced proliferation of Nb2 cells or Baf3 cells stably transfected with hPRL receptors. It also interacts with the hPRL receptor extracellular domain at a 1:1 molar ratio as determined by SEC and SPR analysis.

191

Lyophilized

NaHCO3

22 kDa

E. coli

ARSQVT