Promazine-d6 (hydrochloride)

Promazine-d6 (hydrochloride) (Romtiazin-d6 (hydrochloride) ) is deuterium labeled Promazine (hydrochloride) . Promazine (Romtiazin) hydrochloride is an antipsychotic and a dopamine receptor D2 antagonist. Promazine hydrochloride inhibits dopaminergic neurotransmission[1][2].

1246819-33-9

Romtiazin-d6 (hydrochloride) ; Ampazine-d6 (hydrochloride)

12352005

Dopamine Receptor; Isotope-Labeled Compounds

GPCR/G Protein; Neuronal Signaling; Others

Neuroscience-Neuromodulation

Neurological Disease

[2H]C([2H])([2H])N(C([2H])([2H])[2H])CCCN1C2=CC=CC=C2SC3=CC=CC=C31.Cl

C17H15D6ClN2S

326.92

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Gareri P, et al. Conventional and atypical antipsychotics in the elderly : a review. Clin Drug Investig. 2003;23 (5) :287-322. |[3]Myers PR, et al. Characterization of a depolarizing dopamine response in a vertebrate neuronal somatic cell hybrid. J Cell Physiol. 1977;91 (1) :103-118. |[4]Tatsumi M, et al. Pharmacological profile of neuroleptics at human monoamine transporters. Eur J Pharmacol. 1999;368 (2-3) :277-283.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B1225S/

Isotope-Labeled Compounds

No Development Reported