Propaanzuur-13C3

Propanoic acid-13C3 is the 13C-labeled Propanoic acid. Propanoic acid is an orally active short-chain fatty acid. Propanoic acid can be produced by intestinal bacteria from the metabolism of dietary fiber. Propanoic acid increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Propanoic acid also induces Apoptosis and Autophagy. Propanoic acid reduces HSV-1-induced keratitis. Propanoic acid has anticancer effects against glioblastoma. Propanoic acid exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Propanoic acid can be used in the research of spinal cord injury and Alzheimer's disease[1][2][3][4][5][6][7].

153474-35-2

12352211

H226-H314

Apoptosis; Autophagy; Bacterial; COX; Endogenous Metabolite; HSV; Isotope-Labeled Compounds; NF-κB; NO Synthase; PPAR

Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others; Vitamin D Related/Nuclear Receptor

COVID-19-anti-virus

Cancer; Infection; Inflammation/Immunology; Neurological Disease

O[13C]([13CH2][13CH3])=O

13C3H6O2

77.06

P210-P233-P240-P241-P242-P243-P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P370+P378-P403+P235-P405-P501

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Filippone A, et al. Sodium Propionate Contributes to Tumor Cell Growth Inhibition through PPAR-γ Signaling. Cancers (Basel) . 2022 Dec 29;15 (1) :217. |[3]Filippone A, et al. The anti-inflammatory and antioxidant effects of sodium propionate. International journal of molecular sciences, 2020, 21 (8) : 3026.|[4]Filippone A, et al. Protective effect of sodium propionate in Aβ1-42-induced neurotoxicity and spinal cord trauma. Neuropharmacology. 2020 Apr;166:107977. |[5]Park HS, et al. Sodium propionate exerts anticancer effect in mice bearing breast cancer cell xenograft by regulating JAK2/STAT3/ROS/p38 MAPK signaling. Acta Pharmacol Sin. 2021 Aug;42 (8) :1311-1323. |[6]Sumbria D, et al. Supplementing the Diet with Sodium Propionate Suppresses the Severity of Viral Immuno-inflammatory Lesions. J Virol. 2021 Jan 28;95 (4) :e02056-20. |[7]Lang W, et al. Sodium propionate improves cognitive and memory function in mouse models of Alzheimer's disease. Neurosci Lett. 2022 Nov 20;791:136887.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W780208/

Isotope-Labeled Compounds

No Development Reported