Propeptine

Propeptin is a peptide antibiotic composed of 19 amino acids. Propeptin has weaker activity against Pseudomonas aeruginosa, Mycobacterium monobacterium, and Xanthomonas oryzae. Propeptin has no effect on KB and L1210 cells of tumor cell lines, but has an inhibitory effect on prolyl endopeptidase[1].

146764-30-9

12352005

Antibiotic; Bacterial

Anti-infection

COVID-19-immunoregulation

Infection

O=C([C@@]1([H])N(CCC1)C([C@@H](NC(CNC(C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC2=O)CC3=CNC4=CC=CC=C34)=O)CC(O)=O)=O)CC5=CC=C(C=C5)O)=O)CCCNC(N)=N)=O)C(N[C@@H](CC(C)C)C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@@H]([C@H](O)C)C(N[C@H](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CO)C(N6[C@@H](CCC6)C(O)=O)=O)=O)=O)CC7=CC=CC=C7)=O)=O)CC8=CN=CN8)=O)=O)=O)CC9=CC=CC=C9)=O)=O)=O)=O)CC%10=CC=C(C=C%10)O)=O)N[C@H]2CC%11=CNC%12=CC=CC=C%11%12

C113H142N26O27

2296.49

[1]Ken-ichi Kimura, et al. Novel propeptin analog, propeptin-2, missing two amino acid residues from the propeptin C-terminus loses antibiotic potency. J Antibiot (Tokyo) . 2007 Aug;60 (8) :519-23.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N15055/

Natural Products

No Development Reported