Prosapip1 Antilichaam

Prosapip1 Antibody: Prosapip1 is a binding partner of the postsynaptic density (PSD) protein ProSAP2/Shank3, a major scaffolding protein in excitatory brain synapses. Prosapip1 is thought to bind ProSAP2/Shank3 through ProSAP2/Shank3's PDZ domain and link it in turn to the Spine-associated Rap-Gap (SPAR) . Prosapip1 shares significant homology with another PSD protein, PSD-Zip70, with both coding for a Fez1 domain that can be found in a total of four related protein, forming a novel family of scaffolding molecules termed ‘Fezzins'. Recent studies show that Prosapip1 can be found in endocrine cells in which it is localized primarily in the hormone-storing compartment of these cells, suggesting that Prosapip1 may have other functions in non-neuronal cells.

9762

O60299

NP_055546

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

Prosapip1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1220 - SK-N-SH Cell Lysate

1 mg/mL

Prosapip1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Prosapip1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

ProSAPiP1

ProSAPiP1 protein

Homo sapiens

Wendholt D, Spilker C, Schmitt A, et al. ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein proSAP2/Shank3. J. Biol. Chem.2006; 281:13805-16.

Redecker P, Bockmann J, and Bockers TM. Secretory granules of hypophyseal and pancreatic endocrine cells contain proteins of the neuronal postsynaptic density. Cell Tissue Res.2007; 328:49-55.

Prosapip1 Antibody: PROSAPIP1, KIAA0552, PROSAPIP1, Leucine zipper putative tumor suppressor 3, ProSAP-interacting protein 1, ProSAPiP1

ELISA, WB, IHC-P, IF

7662176

Liquid