Prosapip2 Antilichaam

Prosapip2 Antibody: Prosapip2 (TBKBP1) is essential for signal transduction during viral infection thus plays a major role in the TNF/NF-κ B pathway. It is an adaptor protein that constitutively binds TBK1 (TANK-binding kinase) and IKBKE and may play a role in antiviral innate immunity. Prosapip2 is a 615 amino acid adaptor protein belonging to the fibrillar collagen family, consisting of trimers of identical alpha 1 chains which are linked to each other by interchain disulfide bonds. It has a ubiquitous expression with highest levels in ovary, followed by the neuronal system. Prosapip2 binds to TBK1 and helps in the activation of IRF3 which controls the expression of antiviral genes during infection. Recent studies show that Prosapip2 is an interaction partner of ProSAP2/Shank3 and actin, suggesting a role as a linker molecule between postsynaptic density and the cytoskeleton.

9755

A7MCY6

NP_055541

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Innate Immunity

Prosapip2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1464 - Rat Liver Tissue Lysate

1 mg/mL

Prosapip2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Prosapip2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

TBKBP1

TBK1 binding protein 1

Homo sapiens

Bouwmeester T, Bauch A, Ruffner H, et al. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat. Cell Biol.2004; 6:97-105

Ryzhakov G and Randow F. SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK. EMBO J.2007; 26:3180-90.

Meffert MK, Chang JM, Wiltgen BJ, et al. NF-kappa B functions in synaptic signaling and behavior. Nat. Neurosci.2003; 6:1072-78.

Liebau S, Proepper C, Schmidt T, et al. ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3. Biochem. Biophys. Res Commun.2009; 385:460-5.

Prosapip2 Antibody: SINTBAD, ProSAPiP2, KIAA0775, SINTBAD, TANK-binding kinase 1-binding protein 1, TBK1-binding protein 1

ELISA, WB, IHC-P, IF

7662302

Liquid