PROTAC ALK degrader-4

PROTAC ALK degrader-4 (Compound B8) is an ALK PROTAC degrader with a DC50 of 445.25 nM. PROTAC ALK degrader-4 exhibits excellent anti-proliferative activity against NCI-H2228 and NCI-H3122. PROTAC ALK degrader-4 leads to a significant downregulation of 390 proteins, including IGF-1R and its downstream proteins such as ERK1/2 and STAT3. PROTAC ALK degrader-4 can be used for research on lung adenocarcinoma. (Pink: ALK ligand ; Blue: CRBN ligand (HY-179733) ; Black: linker).

12352005

Anaplastic lymphoma kinase (ALK) ; ERK; IGF-1R; PROTACs; STAT

JAK/STAT Signaling; MAPK/ERK Pathway; PROTAC; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Cancer

CC1=CC(NC2=NC(NC3=CC=CC=C3S(=O)(C(C)C)=O)=C(C=N2)Cl)=C(C=C1C4CCN(CC4)CCCCCCCC(NC5(CCC5)C(NC6C(NC(CC6)=O)=O)=O)=O)OC(C)C

C46H63ClN8O7S

907.56

[1]Huang K, et al. Design, synthesis, and biological evaluation of novel PROTACs based on unnatural dipeptide CRBN ligands. Eur J Med Chem. 2026 Feb 5;303:118387.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-179732/

Reference compound1

No Development Reported