PROTAC HPK1 Degrader-7

PROTAC HPK1 Degrader-7 (compound D02) is a potent and selective PROTAC HPK1 degrader with an DC50 of 3.07 nM. PROTAC HPK1 Degrader-7 exhibits selectivity over GLK. PROTAC HPK1 Degrader-7 induces HPK1 degradation in a CRBN- and proteasome-dependent manner. PROTAC HPK1 Degrader-7 inhibits SLP-76 phosphorylation, induces IL-2 and IFN-γ secretion in human primary T cells. PROTAC HPK1 Degrader-7 can be used for immunology research[1].

12352005

IFNAR; Interleukin Related; MAP4K; PROTACs

Immunology/Inflammation; MAPK/ERK Pathway; PROTAC

Inflammation/Immunology

O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=C(C4=CN=C5OCCNC5=C4C)C=C3)=O)=C1C)NCCN6CCN(CC7CCN(C8=CC=C(N(C(N9)=O)CCC9=O)C=C8F)CC7)CC6

C46H53FN10O5

844.98

[1]Zhang Z, et al. Design, synthesis, and pharmacological evaluation of novel isoindoline-based HPK1 degraders. Eur J Med Chem. 2026 Jan 15;302 (Pt 3) :118366.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-179727/

Reference compound1

No Development Reported

MAP4K1/HPK1