Protohypericine (standaard)

Protohypericin is a compound that can be extracted from Hypericum perforatum. Protohypericin has low photocytotoxicity but can be efficiently photoconverted into Hypericin with high phototoxicity under visible light. Protohypericin can be used in cancer research[1][2][3][4].

548-03-8

12352005

Drug Intermediate

Others

Cancer

O=C(C1=C(O)C=C(C)C=C1C2=C34)C3=C(O)C=C(O)C4=C5C(O)=CC(O)=C6C(C7=C(O)C=C(C)C=C7C2=C65)=O

C30H18O8

506.46

[1]Baugh SF. Simultaneous determination of protopseudohypericin, pseudohypericin, protohypericin, and hypericin without light exposure. J AOAC Int. 2005 Nov-Dec;88 (6) :1607-12.|[2]Liu X, et al. Tumor necrosis targeted radiotherapy of non-small cell lung cancer using radioiodinated protohypericin in a mouse model. Oncotarget. 2015 Sep 22;6 (28) :26400-10.|[3]Kamuhabwa AR, et al. In vitro transport and uptake of protohypericin and hypericin in the Caco-2 model. Int J Pharm. 1999 Oct 15;188 (1) :81-6.|[4]Delaey EM, et al. Photocytotoxicity of protohypericin after photoconversion to hypericin. Planta Med. 1999 Dec;65 (8) :719-22.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N4139R/

Reference Standards