Protrombine (F2) Mouse Monoclonal Antibody [Kloon ID: LBI5B11]

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Carrier-free (BSA/glycerol-free) F2 mouse monoclonal antibody, clone LBI5B11

PT; RPRGL2; THPH1

Homo sapiens coagulation factor II, thrombin (F2), mRNA.

2147

P00734

Unconjugated

Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Regulation of actin cytoskeleton

Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Regulation of actin cytoskeleton

WB 1:500

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, Protease, Secreted Protein

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

F2

https://www.ncbi.nlm.nih.gov/gene/?term=2147

https://www.uniprot.org/uniprot/P00734