PRPF19 Antilichaam - middengebied HRP (ARP43158_T100-HRP)

PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)

PSO4, SNEV, PRP19, UBOX4, hPSO4, NMP200

27339

Q9UMS4

NP_055317

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human PRPF19

PRPF19 plays a role in DNA double-strand break (DSB) repair and pre-mRNA splicing reaction. It binds double-stranded DNA in a sequence-nonspecific manner. PRPF19 acts as a structural component of the nuclear framework. It may also serve as a support for spliceosome binding and activity. It is essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. It also may have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Overexpression of PRPF19 might extend the cellular life span by increasing the resistance to stress or by improving the DNA repair capacity of the cells.In S. cerevisiae, Pso4 has pleiotropic functions in DNA recombination and in error-prone nonhomologous end-joining DNA repair.[supplied by OMIM].

HUWE1; USP4; UBE2D3; SUMO2; CEP76; CEP250; TUBGCP3; CEP57; VCP; UBC; SUMO1; NEDD8; LIN28A; EXOC7; EXOC3; RPA3; RPA2; RPA1; RNF2; SUZ12; EED; rev; MEPCE; SEC13; PARK2; TARDBP; UBD; CSNK2A2; UCHL5; WHSC1; U2AF1; PRCC; HSP90AA1; HSPB1; FN1; RBM10; vif; CDC40

HRP: Horseradish Peroxidase

Polyclonal Antibody

IHC, WB

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

55kDa

Voglauer, R., (2006) Exp. Cell Res. 312 (6), 746-759

Wet Ice

504

PRPF19

PRPF19

Rabbit

Pre-mRNA-processing factor 19

NM_014502

PSVVGAGEPMDLGELVGMTPEIIQKLQDKATVLTTERKKRGKTVPEELVK