PRR5 Antilichaam

PRR5 Antibody: Proline-rich protein 5 (PRR5), also known as Protor-1, is a 388 amino acid protein in Protor family, is thought to act as a tumor suppressor in breast and colorectal tumorigenesis. PRR5 is widely expressed and possesses two RICTOR interaction sites and a C-terminal Proline rich region. It promotes Rapamycin complex 2 (mTORC2) activity. There are four isoforms of PRR5 that are produced as a result of alternative splicing events and these isoforms play an important role in the modulation of platelet-derived growth factor signaling and in the regulation of PDGFR-beta expression.

55615

P85299

NP_851850

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

PRR5 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1220 - SK-N-SH Cell Lysate

1 mg/mL

PRR5 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PRR5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

PRR5 antibody is predicted to not cross-react with other Protor protein family members.

PRR5

Proline rich 5 (renal)

Homo sapiens

Johnstone CN, Castellvi-Bel S, Chang LM, et al. PRR5 encodes a conserved proline-rich protein predominant in kidney: analysis of genomic organization, expression, and mutation status in breast and colorectal carcinomas. Genomics 2005; 85:338-51.

Pearce LR, Huang X, Boudeau J, et al. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem. J. 2007; 405:513-22.

Woo SY, Kim DH, Jun CB, et al. PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor expression and signaling. J. Biol. Chem. 2007; 282:25604-12.

PRR5 Antibody: PP610, PROTOR1, PROTOR-1, FLJ20185k, PP610, Proline-rich protein 5, Protein observed with Rictor-1, Protor-1

ELISA, WB, IHC-P, IF

31317218

Liquid