PSD-95 Antilichaam, Kloon B14

PSD95 (Postsynaptic Density Protein 95), also known as SAP90, is a scaffolding protein in the membrane-associated guanylate kinase (MAGUK) family. It organizes the postsynaptic density by anchoring receptors, ion channels, and signaling molecules at excitatory synapses. PSD95 contains three PDZ domains, an SH3 domain, and a guanylate kinase-like domain. The PDZ domains mediate interactions with NMDA receptors, potassium channels, and neuroligins, facilitating synaptic signaling and plasticity. PSD95 also binds neuronal nitric oxide synthase, linking it to redox signaling. Through its role in AMPA receptor trafficking via Stargazin and TARPs, PSD95 influences synaptic strength and experience-dependent plasticity. Mutations in PSD95 are associated with autism spectrum disorders and cognitive deficits, underscoring its importance in learning and memory and its relevance in neurodegenerative disease research.

Rabbit Anti-Human PSD-95 Recombinant Monoclonal IgG Kappa

PSD 95, PSD-95, PSD95, DLG4, SAP90, Synapse-associated protein 90, Postsynaptic density protein 95, Disks large homolog 4

12352203

Non-hazardous

Non-hazardous

1742

P78352

NP_001308004.1

Fusion protein, AA #77-299 (PDZ domains 1 and 2) of human PSD95.

B14

Unconjugated

Brain

Recombinant Monoclonal

WB | IHC | ICC/IF

Neuroscience | Cell Structure | Post-Synaptic Markers | Cell Signaling | Organelle Markers | Neuron Markers | Cell Markers

AmMagTM Ultra AT Protein A MagBeads

1 µg/ml was sufficient for detection of PSD95 on Rat Brain Membrane lysate.

1mg/ml

WB (1:1000), IHC (1:100), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

PBS pH 7.4, 0.02% Proclin 300, 50% glycerol

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Blue Ice or 4ºC

-20ºC

https://www.stressmarq.com/wp-content/uploads/Antibody-MSDS.pdf

Detects region of PSD95 containing PDZ domains 1 and 2. Does not cross-react with DLG1/SAP97, DLG2/Chapsyn-110 or DLG3/SAP102.

1. Chetkovich D.M., Bunn R.C., Kuo S.H., Kawasaki Y., Kohwi M., and Bredt D.S. (2002) J Neurosci. 22 (15) : 6415-25. 2. Cao J., Viholainen J.I., Dart C., Warwick H.K., Levland M.L. and Courtney M.J. (2005) J Cell Biol. 168 (1) : 117-26. 3. Kennedy M. (1997) Trends in Neurosci. 6: 264-268. 4. Irie M. et al. (1997) Science 277 (5331) : 1511-5. 5. Cai C. et al. (2006) J Biol Chem. 281: 4267-73. 6. Yao W.D. et al. (2004) Neuron 41: 625-38. 7. Cline H. (2005) Curr Biol. 15: R203-5.

Human | Mouse | Rat

Cell membrane, Postsynaptic density, Synapse, Cytoplasm, Cell projection

IgG Kappa

Human