PSMB5 Antilichaam - middengebied: FITC (ARP56467_P050-FITC)

Proteasome (prosome, macropain) subunit, beta type, 5

X, MB1, LMPX

5693

P28074

NP_002788

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human PSMB5

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMB5 is a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit) .The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit) . Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

UBC; AURKA; PSMD14; BMI1; PSMG3; PSMB8; PSMB7; PSMB6; PYCRL; AP3M1; RPP38; PSMB4; PSMB3; PSMB2; PSMB1; PSMA7; PSMA6; PSMA5; PSMA4; PSMA3; PSMA1; KIF5B; EPB41L1; CAST; XRN1; CDK20; CDKL1; PSMA2; PARK2; BAG3; IQCB1; HSP90AB1; HSP90AA1; FN1; IKBKAP; PSMA8; P

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

PSMB5 is supported by BioGPS gene expression data to be expressed in MCF7

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 92%; Zebrafish: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

28kDa

Ewing, R.M., Mol. Syst. Biol. 3, 89 (2007)

Wet Ice

263

PSMB5

PSMB5

Rabbit

Proteasome subunit beta type-5

NM_002797

IVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQ

Beta type-5