PSMB8 Antilichaam - N-terminaal gebied: Biotine (ARP46099_P050-Biotine)

Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)

JMP, ALDD, LMP7, NKJO, D6S216, PRAAS1, PSMB5i, RING10, D6S216E

5696

P28062-2

Human

The immunogen is a synthetic peptide directed towards the N-terminal region of Human PSMB8

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex) . Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit.

IKBKG; PSMB7; PSMB6; PSMB5; PSMB4; PSMB2; PSMB1; PSMA6; PSMA5; PSMA4; PSMA3; PSMA1; HNRNPM; EIF4G1; GCN1L1; CCT2; RPP38; DHX38; PSMA2; PSMA7; PSMA8; USP9X; PSMD8; PSMC5; PSMC4; PSMC3; PSMC2; PSMC1; PSMB3; UBC; PSME2; PSME1; HCVgp1; POMP; TAP2; TAP1; PSMB1

Biotin

Polyclonal Antibody

WB

Affinity Purified

PSMB8 is supported by BioGPS gene expression data to be expressed in HeLa

0.5 mg/ml

Human: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

29kDa

Wet Ice

272

PSMB8

PSMB8

Rabbit

Proteasome subunit beta type-8

MLIGTPTPRDTTPSSWLTSSLLVEAAPLDDTTLPTPVSSGCPGLEPTEFF