PSMC3 Antilichaam - middengebied: Biotine (ARP32929_T100-Biotine)

Proteasome (prosome, macropain) 26S subunit, ATPase, 3

RPT5, TBP1

5702

Q6IBS1

NP_002795

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human PSMC3

PSMC3 is a subunit of the 26S proteasome. 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9

AMOTL2; UBC; PSMD9; PSMC6; PSMC3; KDM1A; HUWE1; SUMO2; PSMD14; MDM2; ASB11; UCHL5; PSMD3; PSMD2; PSMD1; PSMC2; PSMC1; ADRM1; JKAMP; FBXO6; PARK2; BAG3; GADD45A; NOS2; MYC; PSMD13; PSMC4; PSMA8; UBFD1; ECD; STIP1; RANBP9; PSMD6; ZFYVE16; USP14; RUVBL1; PSM

Biotin

Polyclonal Antibody

IHC, WB

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

45kDa

Thompson, H.G., et al., (2004) Int. J. Cancer 111 (3), 338-347

Wet Ice

439

PSMC3

PSMC3

Rabbit

26S protease regulatory subunit 6A

NM_002804

TKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILD

6A