PSMD12 Antilichaam - middengebied: FITC (ARP57840 P050-FITC)

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 12

P55, Rpn5, STISS

5718

Q5RBI3

NP_002807

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human PSMD12

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3.

FUS; HUWE1; SUMO2; UBC; PSMD14; RNF2; KIAA0368; HNRNPA0; TXNL1; SQSTM1; PSMD11; PSMD3; PSMD1; PSMC6; PSMC5; PSMC4; PSMC2; PSMC1; FLNC; FLNB; KCMF1; PARK2; BAG3; RNF11; NPM1; NOS2; PSMD6; PSMD13; PSMD7; UGGT1; PSME3; USP14; PSME1; PSMD10; PSMD8; PSMD4; PSM

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

PSMD12 is supported by BioGPS gene expression data to be expressed in HeLa

0.5 mg/ml

Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 93%; Zebrafish: 85%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

53

Wet Ice

456

PSMD12

PSMD12

Rabbit

26S proteasome non-ATPase regulatory subunit 12

NM_002816

KYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKR

12